What it is
VitamoreD Plus combines Calcifediol (25-hydroxyvitamin D3), the form your blood test measures, with K2 as MK4 and MK7. One mini capsule delivers all three at the optimal dosages.
Traditional Vitamin D supplements are focused on cholecalciferol and K2 (normally as MK7), which requires conversion in your liver to become Calcifediol. VitamoreD Plus contains Calcifediol, also known as 25(OH)D or 25-hydroxyvitamin D. The form that circulates in your blood, the form that your GP measures in your blood tests. Same benefits as traditional vitamin D3 but faster-acting and with more predictable and measurable results.
- Increase vitamin D levels in days, not weeks: Calcifediol skips the liver conversion (Calcifediol doesn't require hepatic 25-hydroxylation). Vitamin D 25(OH)D levels rise faster, which is what your blood test measures.
- Optimised Vitamin K as MK4 and MK7: MK4 is the form our own tissues make from K1 found in leafy greens; MK4 is the main vitamin K found in tissues such as the brain and pancreas, leaving the blood within hours. Blended with MK7, which has a slower absorption rate and a longer half-life, lasting up to 3 days in the body. Taking it daily allows it to build up steady levels.
- Immune Function: Vitamin D contributes to the normal function of the immune system. Your immune cells carry vitamin D receptors (VDR) and depend on circulating Calcifediol to switch on that vitamin D response.
- Fixed K2 amount, not a ratio: contributes to normal blood clotting and the maintenance of normal bones. No vitamin D to K2 ratio has been established, so we chose our amounts from the doses studies actually used.
- Muscle Function: Vitamin D contributes to normal muscle function. Vitamin D receptors (VDR) sit in muscle fibres and their density falls with age.
- Calcium and Phosphorus: Vitamin D contributes to absorption of calcium and phosphorus. We need calcium and phosphorus because they combine to build strong bones and teeth. Calcium drives muscle movement, nerve signals, and heart function, and phosphorus powers cellular energy (ATP) and supports DNA. Absorbing them together is important because they balance each other in the blood and rely on adequate vitamin D levels for absorption and uptake.
How it helps
Vitamin D isn’t actually a vitamin; it’s a prohormone that goes through a two-step conversion process called hydroxylation before your body can actually use it and feel its benefits. All these studies on the benefits aren’t about cholecalciferol; they’re about calcitriol.
Standard vitamin D3 (cholecalciferol), whether your skin makes it or you swallow it, isn't active yet. Your liver first converts it to calcifediol, also called calcidiol or 25-hydroxyvitamin D3 [25(OH)D3]. Your kidneys and other tissues then convert calcifediol into calcitriol, the active hormone with all the benefits the body needs.
VitamoreD Plus delivers Calcifediol in one easy-to-swallow capsule blended with K2 as MK4 and MK7, which rises with your vitamin D dosage. VitamoreD Plus delivers the rapid absorption and sustainable benefits of Calcifediol that are measurable with K2 in two forms.
The three-step process for vitamin D to convert and work
- Cholecalciferol (Vitamin D3): The form made by the skin when exposed to UVB sunlight rays, or the form taken as a traditional D3 supplement. This is the form of vitamin D also stored in body fat. Vitamin D as cholecalciferol is inactive and needs to be converted twice to become the form of Vitamin D (Calcitriol) that delivers the health benefits vitamin D research suggests.
- Calcifediol 25-(OH)D3: The circulating form of vitamin D3, the form screened and measured in your blood test by your GP and practitioner to show if you have too much or too little vitamin D. This is the form of D3 that practitioners refer to as your “vitamin D level” and is the form delivered by VitamoreD in an easy-to-swallow supplement. To become this form, cholecalciferol must first be converted by the CYP2R1 gene in the liver.
- Calcitriol 1,25(OH)2D3: The active hormonal form of vitamin D that is created when Calcifediol is converted in the kidneys. Calcifediol is the form of vitamin D that provides the benefits of vitamin D, i.e., mood, energy, bone and joint health, and immunity.
Calcifediol is measurable, targeted and increases vitamin D levels faster. The problem with traditional Cholecalciferol supplements is that they require fat, or adequate amounts of cholesterol, if you are trying to synthesise vitamin D from the sun. But it still needs to be converted by the CYP2R1 gene in the liver. This gene conversion in the liver can be reduced and even suppressed, especially in people who have chronically deficient vitamin D levels, are obese, are fasting and/or have type 1 or type 2 diabetes. This is why Calcifediol exists: it bypasses this step, doesn’t require liver conversion, is fat-soluble, and doesn't care about your weight or any condition you are suffering from.
Where Vitamin K2 Fits within VitamoreD Plus and why take 2 forms (MK4 + MK7)
Vitamin D increases the body's production of certain proteins, including osteocalcin in bone and matrix Gla protein (MGP). Those proteins only work once vitamin K has modified them, a process called carboxylation. Vitamin D helps make the proteins; vitamin K switches them on.
We added Vitamin K2 in two forms, MK4 and MK7, because they behave differently in the body. MK7, which is well researched and has a longer half-life (3 days), builds steady levels when taken daily and breaks down slowly in the blood. Whereas MK4 is the form of Vitamin K we get from food such as leafy greens, and it is the main form of vitamin K found in our tissues, brain and pancreas. Vitamin K2, as MK-4, is cleared from circulation within a few hours. Because it is rapidly metabolised by the liver, higher clinical doses are utilised in studies to help target peripheral tissue health and bone density.
Using both K2 forms gives a broader profile than picking the one that's easier to formulate around.
Benefits
- Pre active form of vitamin D – up to five times better absorbed by the body
- Helps the body store vitamin D for extended periods
- Three point two times more potent than generic Vitamin D3 as cholecalciferol
- Bypasses the liver and circulates in the blood, ready for conversion
- Take less, absorb more
- Easy swallow tablets
- Vegan, with no animal products, additives or unnecessary ingredients
Ingredients
60 capsules per pouch = 30 to 60 days' supply.
Per 1 easy-swallow VitamoreD Plus Capsule:
- 10 mcg (1000 I.U.) Dyna-Cal 25-OH Vitamin D3 (Calcifediol).
- 90 mcg Vitamin K2 as Menaquinone-7 (MK-7)
- 500 mcg Vitamin K2 as Menaquinone-4 (MK-4)
Other Natural Ingredients: rice flour and bamboo silica. Capsule shell: hydroxypropyl methylcellulose (HPMC).
Vitamin D Potency - IU of Calcifediol
Vitamin D Potency is defined in International Units (IU). Research has shown that the form of Vitamin D in VitamoreD (Calcifediol, also known as Calcidiol or 25-hydroxy D3) can be 3.2 to 5 x more potent than cholecalciferol because of how it works and activates in the body. In 2024, the EFSA re-evaluated Calcifediol and agreed on the following:
Cholecalciferol in International Units.
- 1 mcg (µg) of Cholecalciferol = 40 IU.
- 10 mcg of Cholecalciferol = 400 I.U.
Calcifediol in International Units.
- 0.4 mcg (µg) of Calcifediol = 40 IU.
- 10 mcg of Calcifediol = 1000 I.U.
Why Calcifediol was originally 2000 IU per 10 mcg tablet.
Made from natural sunshine enriched desmesterol, with no animal products, additives or unnecessary ingredients. Suitable for those following a vegan or vegetarian lifestyle.
A note on potency
Each country interprets the research on the potency of calcifediol differently. Vitamin D potency is defined in International Units (IU). Research has shown that calcifediol can be between three point two and five times more potent than cholecalciferol due to how it works and activates in the body.
In the UK and EU: 10 mcg Calcifediol = 2000 IU
In the USA: 10 mcg Calcifediol = 1200 IU
Important information
How to take
Pack size
One pouch provides a 60 day supply.
Batch testing
Third party batch tested in our UK laboratory: download the latest batch certificate.
Frequently Asked Questions
Why is calcifediol different from cholecalciferol?
Cholecalciferol requires conversion in the liver to become usable as vitamin D, while calcifediol is the next step in this conversion process and is closer to the active form your body needs, called calcitriol.
Oral calcifediol results in a more rapid increase in serum 25OHD compared to cholecalciferol. It is also more potent because it bypasses the liver and goes directly to the kidneys, meaning lower dosages are needed to achieve optimal vitamin D levels.
Is calcifediol safe to take?
Calcifediol is used to increase the active form of vitamin D, which is important for maintaining healthy bones and teeth and supporting the immune system. Please check with your healthcare practitioner before use if you have a medical condition, are taking medication, or are pregnant or breastfeeding.
Can I take Vitamin K2 with VitamoreD?
Yes, you can take Vitamin K2 with VitamoreD. For those with a K2 deficiency, studies suggest that it may be useful to support heart and bone health when taken in combination with your daily dose of VitamoreD.
Is there research on calcifediol?
Yes. Research supports calcifediol for improving vitamin D levels compared to traditional cholecalciferol (Vitamin D3). Key studies include:
PMID: 29713796
PMID: 28187226
PMID: 34101900
PMID: 34862422
PMID: 35565910
Is VitamoreD vegan?
Yes. VitamoreD is vegan. It is made from natural sunshine enriched desmesterol, with no animal products, additives or unnecessary ingredients, making it suitable for those following a vegan or vegetarian lifestyle.
Disclaimer
Our products and services do not diagnose, treat or cure any illness or disease, and do not replace medical advice from your doctor or practitioner. Food supplements should not be used as a substitute for a varied diet. Information on this website is for educational purposes only and does not replace personalised medical advice. If you are pregnant or breastfeeding, taking prescribed medication or have a medical condition, please consult your healthcare practitioner before starting any new supplement.